Description
Product Characteristics: FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. SUBCELLULAR LOCATION: Golgi apparatus âÄ° trans-Golgi network membrane, Multi-pass membrane protein. Note: Found in vesicles Tissue specificity: Expressed in brain, especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.,SLC30 Family,Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6, ZNT6
Target Information: Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]